The TRPV4 channel: structure-function relationship and promiscuous gating behaviour.

Bernd Nilius; Hiroyuki Watanabe; Joris Vriens

doi:10.1007/s00424-003-1028-9

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The TRPV4 channel: structure-function relationship and promiscuous gating behaviour.

Bernd Nilius·Hiroyuki Watanabe·Joris Vriens

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Abstract

Transient receptor potential (TRP) channels provide an enormous variability of Ca(2+) influx mechanisms triggered by a wide range of stimuli. In this review, we discuss the activation properties of the Ca(2+)- and Mg(2+)-permeable TRP channel of the vanilloid subfamily TRPV4. This channel is activated by various physical and chemical stimuli, such as cell swelling, heat, phorbols and, probably, by endogenous ligands, which are able to induce Ca(2+) entry. Not much is known about the regulation of this channel. We will refer only to a mechanism of Ca(2+)-dependent inhibition of TRPV4. Possible functional roles of this channel will be correlated with its observed expression pattern. Finally, we discuss the structural determinants of TRPV4 channel function.

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Animals Calcium Cation Transport Proteins Hot Temperature Humans Ion Channel Gating Ion Channels Ligands Mechanoreceptors Structure-Activity Relationship TRPV Cation Channels Journal Article Research Support, Non-U.S. Gov't Review

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Bernd Nilius, Hiroyuki Watanabe, Joris Vriens. 2003-04-25. The TRPV4 channel: structure-function relationship and promiscuous gating behaviour.. https://doi.org/10.1007/s00424-003-1028-9

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