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Behçet's disease.

Shunsei Hirohata·Hirotoshi Kikuchi
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Abstract

Behçet's disease is characterized by recurrent aphthous stomatitis, uveitis, genital ulcers, and skin lesions. The role of the HLA-B*51 gene has been confirmed in recent years, although its contribution to the overall genetic susceptibility to Behçet's disease was estimated to be only 19%. The production of a variety of cytokines by T cells activated with multiple antigens has been shown to play a pivotal role in the activation of neutrophils. As regards the treatment, anti-tumor necrosis factor alpha therapy has been shown to be effective for mucocutaneous symptoms as well as for sight-threatening panuveitis, although a randomized, controlled trial is required.

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AnimalsBehcet SyndromeGenetic Predisposition to DiseaseHLA-B AntigensHLA-B51 AntigenHumansJournal ArticleReview

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BibTeXRIS

Shunsei Hirohata, Hirotoshi Kikuchi. 2003-04-02. Behçet's disease.. https://doi.org/10.1186/ar757

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