Mapping functional residues onto integrin crystal structures.

Martin J Humphries; Emlyn J H Symonds; A Paul Mould

doi:10.1016/s0959-440x(03)00035-6

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Mapping functional residues onto integrin crystal structures.

Martin J Humphries·Emlyn J H Symonds·A Paul Mould

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Abstract

Historical data, available in the literature, concerning the sites responsible for integrin-ligand binding and activation may now be transposed onto recently solved crystal structures of integrin dimers and functional domains. The data were obtained through studies of natural and engineered mutations within integrins, and analyses of the epitopes for function-altering monoclonal antibodies. In the past two years, this combining of structure and function has led to the development of novel hypotheses for the mechanisms of integrin regulation.

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Binding Sites Crystallography Epitope Mapping Integrins Ligands Models, Molecular Protein Binding Protein Conformation Protein Structure, Tertiary Protein Subunits Structure-Activity Relationship Journal Article Research Support, Non-U.S. Gov't Review

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Martin J Humphries, Emlyn J H Symonds, A Paul Mould. 2003. Mapping functional residues onto integrin crystal structures.. https://doi.org/10.1016/s0959-440x(03)00035-6

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