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Intrinsic T cell defects in systemic autoimmunity.

Philip L Kong·Jared M Odegard·Farida Bouzahzah·Jin-Young Choi·Leah D Eardley·Christina E Zielinski·Joseph E Craft
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Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of T cell tolerance to nuclear antigens. Studies in mice and humans have demonstrated that T cells from individuals with lupus are abnormal. Here, we review the known T cell defects in lupus and their possible biochemical nature, genetic causes, and significance for lupus pathogenesis.

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AnimalsHumansLupus Erythematosus, SystemicMiceT-LymphocytesJournal ArticleReview

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Philip L Kong, Jared M Odegard, Farida Bouzahzah, Jin-Young Choi, Leah D Eardley, Christina E Zielinski, Joseph E Craft. 2003. Intrinsic T cell defects in systemic autoimmunity.. https://doi.org/10.1111/j.1749-6632.2003.tb06033.x

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