Analyzing randomized dose finding studies with a primary and a secondary endpoint.

Ludwig A Hothorn; Gernot Wassmer

doi:10.1081/bip-120019273

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Analyzing randomized dose finding studies with a primary and a secondary endpoint.

Ludwig A Hothorn·Gernot Wassmer

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Abstract

The identification of the minimum effective dose for both the primary and secondary endpoint under a priori importance ordering assumption is described. Stepwise testing procedures, which conditionally test each elementary hypotheses at level alpha, but control the experimentwise Type I error rate, can be used.

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Dose-Response Relationship, Drug Endpoint Determination Randomized Controlled Trials as Topic Journal Article

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Ludwig A Hothorn, Gernot Wassmer. 2003. Analyzing randomized dose finding studies with a primary and a secondary endpoint.. https://doi.org/10.1081/bip-120019273

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