Mitochondrial membrane permeabilisation by Bax/Bak.

Mauro Degli Esposti; Caroline Dive

doi:10.1016/s0006-291x(03)00617-x

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Mitochondrial membrane permeabilisation by Bax/Bak.

Mauro Degli Esposti·Caroline Dive

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Abstract

Recent studies on cells derived from mice deficient in both multi-domain pro-apoptotic genes of the Bcl-2 family, Bax and Bak, suggest that one or other of these proteins are required for the release of apoptogens such as cytochrome c from mitochondria. In addition BH-3 only proteins of this family such as Bid are suggested to act as critical death inducing ligands via interactions with pro- and anti-apoptotic Bcl-2 family proteins with Bax or Bak at the mitochondrial surface. Despite this increase in knowledge it remains unclear precisely how Bak and Bax promote outer mitochondrial membrane (OMM) permeabilisation. We suggest that Bax and Bak may not operate in precisely the same manner and evaluate the current models for their function. We also consider the emerging information that lipid-protein interactions may be crucial to the actions of Bax and Bak.

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Animals Apoptosis BH3 Interacting Domain Death Agonist Protein Carrier Proteins Cell Membrane Permeability Dimerization Intracellular Membranes Membrane Proteins Mice Mitochondria Models, Biological Peptides Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-2 bcl-2 Homologous Antagonist-Killer Protein bcl-2-Associated X Protein bcl-X Protein Journal Article Review

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Mauro Degli Esposti, Caroline Dive. 2003-05-09. Mitochondrial membrane permeabilisation by Bax/Bak.. https://doi.org/10.1016/s0006-291x(03)00617-x

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