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Human B-blast specific target determinants in CML: a panel study.

H E Johnsen
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Abstract

The B blast specific target determinant phenotype defined by cytotoxic lymphocytes and the HLA-DR phenotype was tested for correlation in two panel studies. First, CTL reagents with B blast specificity were selected from CTLs educated between HLA-A, B, (C) identical unrelated donors giving no cytotoxicity with specific T blasts, resulting in free selection of panel B blasts used as targets. Second, CTLs educated between HLA non-identical unrelated donors giving cytotoxicity against specific T as well a B blast targets could be seen with negative reactions against T blasts but positive reactions against B blasts of selected panel members giving, in this set up, a free selection of donors cocultured for education of CTLs. These panel studies showed that HLA-DR associated B blast specific target determinants can be identified by CTLs, indicating that the HLA system codes for these determinants either through gene products of a locus closely linked to or identical with the HLA-DR locus.

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B-LymphocytesHLA-A AntigensHLA-B AntigensHLA-C AntigensHLA-DR AntigensHumansImmunity, CellularImmunologic MemoryT-Lymphocytes, CytotoxicJournal ArticleResearch Support, Non-U.S. Gov't

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H E Johnsen. 1980. Human B-blast specific target determinants in CML: a panel study.. https://doi.org/10.1111/j.1399-0039.1980.tb00904.x

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