Genome function and nuclear architecture: from gene expression to nanoscience.

Timothy P O'Brien; Carol J Bult; Christoph Cremer; Michael Grunze; Barbara B Knowles; Jorg Langowski; James McNally; Thoru Pederson; Joan C Politz; Ana Pombo; Gunter Schmahl; Joachim P Spatz; Roel van Driel

doi:10.1101/gr.946403

PubMed · 12743020

Genome function and nuclear architecture: from gene expression to nanoscience.

Timothy P O'Brien·Carol J Bult·Christoph Cremer·Michael Grunze·Barbara B Knowles·Jorg Langowski·James McNally·Thoru Pederson·Joan C Politz·Ana Pombo·Gunter Schmahl·Joachim P Spatz·Roel van Driel

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Abstract

Biophysical, chemical, and nanoscience approaches to the study of nuclear structure and activity have been developing recently and hold considerable promise. A selection of fundamental problems in genome organization and function are reviewed and discussed in the context of these new perspectives and approaches. Advancing these concepts will require coordinated networks of physicists, chemists, and materials scientists collaborating with cell, developmental, and genome biologists.

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Animals Cell Nucleus Computational Biology Gene Expression Regulation Genome Humans Nanotechnology Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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Timothy P O'Brien, Carol J Bult, Christoph Cremer, Michael Grunze, Barbara B Knowles, Jorg Langowski, James McNally, Thoru Pederson, Joan C Politz, Ana Pombo, Gunter Schmahl, Joachim P Spatz, Roel van Driel. 2003-05-12. Genome function and nuclear architecture: from gene expression to nanoscience.. https://doi.org/10.1101/gr.946403

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