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Modeling network dynamics: the lac operon, a case study.

José M G Vilar·Călin C Guet·Stanislas Leibler
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Abstract

We use the lac operon in Escherichia coli as a prototype system to illustrate the current state, applicability, and limitations of modeling the dynamics of cellular networks. We integrate three different levels of description (molecular, cellular, and that of cell population) into a single model, which seems to capture many experimental aspects of the system.

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AnimalsComputational BiologyEscherichia coliHumansLac OperonLactoseModels, BiologicalNonlinear DynamicsJournal ArticleReview

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José M G Vilar, Călin C Guet, Stanislas Leibler. 2003-05-12. Modeling network dynamics: the lac operon, a case study.. https://doi.org/10.1083/jcb.200301125

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