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PubMed · 12746548

Do we need zinc to think?

Yang V Li·Christopher J Hough·John M Sarvey
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Abstract

Chelatable Zn(2+), which is found in the synaptic vesicles of certain glutamatergic neurons in several regions of the forebrain, is released during neuronal activity. Zn(2+) exhibits numerous effects on ligand-gated and voltage-dependent ion channels, and released Zn(2+) is therefore likely able to modulate synaptic transmission. The physiologically relevant actions of Zn(2+), however, have remained unclear. Recent research exploiting improved Zn(2+)-sensitive optical probes has suggested some intriguing effects for synaptically released Zn(2+), including heterosynaptic regulation of N-methyl-D-aspartate (NMDA) receptor function, and a novel role as a trans-synaptic second messenger that may enter postsynaptic neurons to modulate various signal transduction pathways.

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AnimalsBrain ChemistryHumansSecond Messenger SystemsSynaptic TransmissionThinkingZincJournal ArticleReview

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Yang V Li, Christopher J Hough, John M Sarvey. 2003-05-13. Do we need zinc to think?. https://doi.org/10.1126/stke.2003.182.pe19

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