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PubMed · 12746716

[Intrathecal therapy for bladder hyperreflexia].

P Denys·A Even-Schneider·O Rémy-Néris·D Ben Smaïl·E Chartier-Kastler·B Bussel
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Abstract

Intrathecal clonidine was tested for the control of bladder hyperreflexia resistant to pararsympathicolytic drugs in spinal cord injured patients. Urodynamic parameters were significantly improved after acute bolus of intrathecal low doses of clonidine. Unfortunately, the chronic intrathecal infusion of clonidine induced cardiovascular side-effects. Intrathecal baclofen did not modified significantly neurogenic bladder dysfunction from spinal lesion. But intrathecal baclofen modified penile erection quality and impaired the ejaculation reflex induced by penile vibratory stimulation in the same population.

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Adrenergic alpha-AgonistsBaclofenClonidineFemaleHumansInjections, SpinalMaleMuscle Relaxants, CentralSexual Dysfunction, PhysiologicalSpinal Cord InjuriesUrinary Bladder, NeurogenicEnglish AbstractJournal ArticleReview

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P Denys, A Even-Schneider, O Rémy-Néris, D Ben Smaïl, E Chartier-Kastler, B Bussel. 2003. [Intrathecal therapy for bladder hyperreflexia].. https://pubmed.ncbi.nlm.nih.gov/12746716/

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