Adenovirus DNA replication.

H Liu; J H Naismith; R T Hay

doi:10.1007/978-3-662-05597-7_5

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PubMed · 12747549

Adenovirus DNA replication.

H Liu·J H Naismith·R T Hay

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Abstract

Replication of the adenovirus genome is catalysed by adenovirus DNA polymerase in which the adenovirus preterminal protein acts as a protein primer. DNA polymerase and preterminal protein form a heterodimer which, in the presence of the cellular transcription factors NFI/CTFI and NFIII/Oct-1, binds to the origin of DNA replication. DNA replication is initiated by DNA polymerase mediated transfer of dCMP onto preterminal protein. Further DNA synthesis is catalysed by DNA polymerase in a strand displacement mechanism which also requires adenovirus DNA binding protein. Here, we discuss the role of individual proteins in this process as revealed by biochemical analysis, mutagenesis and molecular modelling.

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Adenoviridae CCAAT-Enhancer-Binding Proteins DNA Replication DNA, Viral DNA-Binding Proteins DNA-Directed DNA Polymerase Host Cell Factor C1 NFI Transcription Factors Octamer Transcription Factor-1 Transcription Factors Journal Article Review

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H Liu, J H Naismith, R T Hay. 2003. Adenovirus DNA replication.. https://doi.org/10.1007/978-3-662-05597-7_5

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