Deciphering skeletal patterning: clues from the limb.

Francesca V Mariani; Gail R Martin

doi:10.1038/nature01655

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Deciphering skeletal patterning: clues from the limb.

Francesca V Mariani·Gail R Martin

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Abstract

Even young children can distinguish a Tyrannosaurus rex from a Brontosaurus by observing differences in bone size, shape, number and arrangement, that is, skeletal pattern. But despite our extensive knowledge about cartilage and bone formation per se, it is still largely a mystery how skeletal pattern is established. Much of what we do know has been learned from studying limb development in chicken and mouse embryos. Based on the data from such studies, models for how limb skeletal pattern is established have been proposed and continue to be hotly debated.

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Animals Body Patterning Bone and Bones Cartilage Extremities Gene Expression Regulation, Developmental Joints Models, Biological Signal Transduction Journal Article Review

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Francesca V Mariani, Gail R Martin. 2003-05-15. Deciphering skeletal patterning: clues from the limb.. https://doi.org/10.1038/nature01655

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