Solid-phase synthesis of a pepticinnamin E library.

Michael Thutewohl; Herbert Waldmann

doi:10.1016/s0968-0896(03)00159-7

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Solid-phase synthesis of a pepticinnamin E library.

Michael Thutewohl·Herbert Waldmann

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Abstract

Pepticinnamin E is a naturally occurring bisubstrate inhibitor of farnesyltransferase. Based on the structure of the natural product, a compound library was synthesized by variation of eight structural parameters. Following three different routes, a total of 51 analogues was synthesized on the polymeric support in 6-11-step parallel syntheses. Overall yields ranged from 3 to 63%, and the compounds were obtained with >90% purity.

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Alkyl and Aryl Transferases Enzyme Inhibitors Farnesyltranstransferase Inhibitory Concentration 50 Oligopeptides Peptide Library ras Proteins Journal Article Research Support, Non-U.S. Gov't

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Michael Thutewohl, Herbert Waldmann. 2003-06-12. Solid-phase synthesis of a pepticinnamin E library.. https://doi.org/10.1016/s0968-0896(03)00159-7

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