Glycoprotein Ib-IX-V.

R K Andrews; E E Gardiner; Y Shen; J C Whisstock; M C Berndt

doi:10.1016/s1357-2725(02)00280-7

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PubMed · 12757754

Glycoprotein Ib-IX-V.

R K Andrews·E E Gardiner·Y Shen·J C Whisstock·M C Berndt

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Abstract

Glycoprotein (GP) Ib-IX-V is a remarkable platelet adhesion receptor of the leucine-rich repeat family. It has evolved to fulfil its major function of initiating platelet aggregation (thrombus formation) at high-shear stress in flowing blood. In addition to binding von Willebrand factor (vWF) in subendothelial matrix or plasma to trigger platelet aggregation, GPIb-IX-V also binds counter-receptors, alphaMbeta2 (Mac-1) on neutrophils or P-selectin on activated platelets or endothelial cells. GPIb-IX-V ligands also include alpha-thrombin, clotting factors XI/XIIa, and high-molecular-weight kininogen. Interactions involving GPIb-IX-V are therefore central to vascular processes of thrombosis and inflammation, and the receptor is under intense scrutiny as a potential therapeutic target.

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Animals Binding Sites Humans Platelet Aggregation Platelet Glycoprotein GPIb-IX Complex Protein Structure, Quaternary Thrombosis von Willebrand Factor Journal Article Review

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R K Andrews, E E Gardiner, Y Shen, J C Whisstock, M C Berndt. 2003. Glycoprotein Ib-IX-V.. https://doi.org/10.1016/s1357-2725(02)00280-7

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