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Current CML therapy: progress and dilemma.

R Hehlmann
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Abstract

Rarely has progress in treatment of leukemia been as dramatic and convincing as with the BCR-ABL tyrosine kinase inhibitor imatinib.(1) Imatinib induces remissions of CML as fast as hydroxyurea, achieves rates of cytogenetic remissions that by far exceed those induced by interferon alpha and has a toxicity profile as favourable as that of hydroxyurea and much superior to that of interferon alpha.(2) In addition, the causal approach of this new drug, which may well serve as a model for new treatment modalities in other neoplasias is reassuring.

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Antineoplastic AgentsBenzamidesClinical Trials as TopicEnzyme InhibitorsFusion Proteins, bcr-ablHumansHydroxyureaImatinib MesylateInterferon-alphaLeukemia, Myelogenous, Chronic, BCR-ABL PositivePiperazinesProtein-Tyrosine KinasesPyrimidinesStem Cell TransplantationJournal ArticleReview

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R Hehlmann. 2003. Current CML therapy: progress and dilemma.. https://doi.org/10.1038/sj.leu.2402951

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