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TRPM2 Ca2+ permeable cation channels: from gene to biological function.

Anne-Laure Perraud·Carsten Schmitz·Andrew M Scharenberg
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Abstract

TRPM2 is a recently identified TRPM family cation channel which is unique among known ion channels in that it contains a C-terminal domain which is homologous to the NUDT9 ADP-ribose hydrolase and possesses intrinsic ADP-ribose hydrolase activity. Here, available information on the TRPM2 gene, transcripts, predicted protein products, and assembled multimeric channels is comprehensively reviewed and synthesized to highlight important areas for future work and provide insight into potential biological function(s) of TRPM2 channels.

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Adenosine Diphosphate RiboseAmino Acid SequenceAnimalsCalciumCalcium SignalingHumansIon ChannelsMembrane ProteinsMolecular Sequence DataPyrophosphatasesSequence Homology, Amino AcidTRPM Cation ChannelsJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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Anne-Laure Perraud, Carsten Schmitz, Andrew M Scharenberg. TRPM2 Ca2+ permeable cation channels: from gene to biological function.. https://doi.org/10.1016/s0143-4160(03)00057-5

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