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PubMed · 12769835

A nuclear MAL-function links Rho to SRF.

Jeffrey Settleman
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Abstract

The activation of SRF-mediated transcription in response to Rho GTPase-induced actin assembly involves the ability of SRF to sense changes in the cellular level of actin monomers. An article in the May 2 issue of Cell identifies the transcription factor MAL as an actin binding protein that functions as an SRF coactivator and whose translocation from cytoplasm to nucleus depends on its dissociation from actin monomers (Miralles et al., 2003).

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ActinsActive Transport, Cell NucleusAnimalsCell NucleusEukaryotic CellsGene Expression RegulationHumansIntracellular Signaling Peptides and ProteinsMAP Kinase Kinase KinasesProtein Serine-Threonine KinasesSerum Response Factorrho GTP-Binding Proteinsrho-Associated KinasesJournal ArticleReview

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Jeffrey Settleman. 2003. A nuclear MAL-function links Rho to SRF.. https://doi.org/10.1016/s1097-2765(03)00189-8

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