Perirhinal cortex lesions impair context aversion learning.

Dana J Howse; Amanda S Squires; Gerard M Martin; Darlene M Skinner

doi:10.1101/lm.57803

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Perirhinal cortex lesions impair context aversion learning.

Dana J Howse·Amanda S Squires·Gerard M Martin·Darlene M Skinner

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Abstract

Rats with perirhinal cortex lesions were compared with sham controls on a conditional discrimination in which saccharin was paired with LiCl in context 1, but paired with saline in context 2. Perirhinal-lesioned rats were slightly slower to acquire the discrimination but reached control levels by the end of acquisition. Both groups showed transfer to familiar tap water, consuming less in context 1 than in context 2. Unlike sham rats, perirhinal rats failed to show an aversion to context 1 on a place choice test. These data provide neuroanatomical support for the postulated difference between Pavlovian conditioning and conditional learning.

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Animals Avoidance Learning Conditioning, Psychological Discrimination Learning Male Parahippocampal Gyrus Rats Rats, Long-Evans Comparative Study Journal Article Research Support, Non-U.S. Gov't

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Dana J Howse, Amanda S Squires, Gerard M Martin, Darlene M Skinner. Perirhinal cortex lesions impair context aversion learning.. https://doi.org/10.1101/lm.57803

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