Understanding the function of CD1-restricted T cells.

Michael S Vincent; Jenny E Gumperz; Michael B Brenner

doi:10.1038/ni0603-517

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Understanding the function of CD1-restricted T cells.

Michael S Vincent·Jenny E Gumperz·Michael B Brenner

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Abstract

CD1 molecules bind foreign lipid antigens as they survey the endosomal compartments of infected antigen-presenting cells. Unlike T cells that recognize CD1-restricted foreign lipids, CD1-restricted T cells that are self-antigen-reactive function as 'auto-effectors' that are rapidly stimulated to carry out helper and effector functions upon interaction with CD1-expressing antigen-presenting cells. The functional distinctions between subsets of CD1-restricted T cells, and the pathways by which these cells both influence the inflammatory and tolerogenic effects of dendritic cells and activate natural killer cells and other lymphocytes, provide insight into how CD1-restricted T cells regulate antimicrobial responses, antitumor immunity and the balance between tolerance and autoimmunity.

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Animals Antigen Presentation Antigens, CD1 Autoimmunity Dendritic Cells Humans Immune Tolerance Models, Molecular Mycolic Acids T-Lymphocytes Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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Michael S Vincent, Jenny E Gumperz, Michael B Brenner. 2003. Understanding the function of CD1-restricted T cells.. https://doi.org/10.1038/ni0603-517

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