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Progesterone does not influence vascular function in postmenopausal women.

Suzy Y Honisett·Ben Pang·Lily Stojanovska·Krishnankutty Sudhir·Paul A Komesaroff
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Abstract

BACKGROUND: The protective functions of oestrogen therapy alone on cardiovascular risk parameters are well established; however, the action of progesterone on vascular parameters in an oestrogen-deprived environment is less clear. OBJECTIVES: To examine the effects of progesterone alone on vascular function and hormone levels in postmenopausal women. DESIGN: In a randomized, double-blind, cross-over design study, 20 healthy postmenopausal women were tested before and after 6 weeks of treatment with micronized progesterone (100 mg/daily) and matching placebo. METHODS: Tests included measurement of sex hormones and gonadatropin levels, lipids and measures of surrogate markers of vascular function including, blood pressure, flow-mediated dilation of the brachial artery, systemic arterial compliance and cutaneous vascular reactivity. RESULTS: The mean (+/- SEM) age of subjects was 56.4 +/- 2.7 years and the average body mass index at the baseline visit was 27.1 +/- 1.0 kg/m2. Progesterone levels increased as a result of progesterone treatment (0.9 +/- 0.2 to 9.5 +/- 2.3 nmol/l, P = 0.001), whereas follicle-stimulating hormone levels decreased (75.1 +/- 11.4 to 67.6 +/- 10.0, P = 0.001). Systemic arterial compliance, flow mediated dilation, cutaneous vascular reactivity, blood pressure, body mass index, plasma levels of cholesterol, lipids and oestrogen were unchanged. CONCLUSIONS: We conclude that progesterone given without oestrogen does not adversely affect vascular function in postmenopausal women.

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AgedBlood PressureComplianceCross-Over StudiesDouble-Blind MethodEndothelium, VascularEstrogen Replacement TherapyFemaleHumansLipoproteinsMiddle AgedProgesteroneVasodilationClinical TrialJournal ArticleRandomized Controlled TrialResearch Support, Non-U.S. Gov't

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Suzy Y Honisett, Ben Pang, Lily Stojanovska, Krishnankutty Sudhir, Paul A Komesaroff. 2003. Progesterone does not influence vascular function in postmenopausal women.. https://doi.org/10.1097/00004872-200306000-00014

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