Rocks: multifunctional kinases in cell behaviour.

Kirsi Riento; Anne J Ridley

doi:10.1038/nrm1128

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Rocks: multifunctional kinases in cell behaviour.

Kirsi Riento·Anne J Ridley

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Abstract

ROCKs, or Rho kinases, are serine/threonine kinases that are involved in many aspects of cell motility, from smooth-muscle contraction to cell migration and neurite outgrowth. Recent experiments have defined new functions of ROCKs in cells, including centrosome positioning and cell-size regulation, which might contribute to various physiological and pathological states.

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Animals Apoptosis Gene Expression Regulation Humans Insulin Intracellular Signaling Peptides and Proteins Models, Biological Muscle, Smooth Phagocytosis Phosphorylation Phylogeny Protein Isoforms Protein Serine-Threonine Kinases Signal Transduction rho-Associated Kinases Journal Article Research Support, Non-U.S. Gov't Review

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Kirsi Riento, Anne J Ridley. 2003. Rocks: multifunctional kinases in cell behaviour.. https://doi.org/10.1038/nrm1128

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