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Compulsive behavior in the 5-HT2C receptor knockout mouse.

Jennifer M Chou-Green·Todd D Holscher·Mary F Dallman·Susan F Akana
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Abstract

The efficacy of serotonergic pharmacotherapy indicates that serotonin (5-HT) plays a role in the treatment, if not the etiology, of obsessive-compulsive disorder (OCD). While some clinical evidence implicates 5-HT(2C) receptors in this disorder, a definitive function has yet to be validated. We hypothesized that 5-HT(2C) receptor knockout (KO) mice may display compulsive-like behavior. This paper describes characterization of several distinct, highly organized behaviors in mice lacking functional 5-HT(2C) receptors, which supports a compulsive-like syndrome.Compulsive-like behavior was assessed in male 5-HT(2C) receptor KO and wildtype (WT) mice. Chewing of non-nutritive clay, chewing patterns on plastic-mesh screens, and the frequency of head dipping were measured. 5-HT(2C) receptor KO mice chewed more clay, produced a distinct pattern of "neat" chewing of plastic screens and exhibited reduced habituation of head dipping activity compared to WT mice. We conclude that the 5-HT(2C) receptor null mutant mouse provides a promising model of compulsive behavior and a means to further explore the role of 5-HT in OCD.

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AnimalsCompulsive BehaviorEatingExploratory BehaviorGenotypeHabituation, PsychophysiologicHyperphagiaMasticationMiceMice, KnockoutReceptor, Serotonin, 5-HT2CJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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Jennifer M Chou-Green, Todd D Holscher, Mary F Dallman, Susan F Akana. 2003. Compulsive behavior in the 5-HT2C receptor knockout mouse.. https://doi.org/10.1016/s0031-9384(03)00047-7

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