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ZDOCK predictions for the CAPRI challenge.

Rong Chen·Weiwei Tong·Julian Mintseris·Li Li·Zhiping Weng
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Abstract

The CAPRI Challenge is a blind test of protein-protein-docking algorithms that predict the complex structure from the crystal structures of the interacting proteins. We participated in both rounds of this blind test and submitted predictions for all seven targets, relying mainly on our Fast Fourier Transform based algorithm ZDOCK that combines shape complementarity, desolvation, and electrostatics. Our group made good predictions for three targets and had at least some success with three others. Implications of the treatment of prior biological information as well as contributions of manual inspection to docking predictions are also discussed.

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AlgorithmsAnimalsAntibodiesAntigens, ViralBacterial ProteinsBinding SitesCapsid ProteinsExotoxinsHemagglutininsMacromolecular SubstancesMembrane ProteinsModels, MolecularPhosphoenolpyruvate Sugar Phosphotransferase SystemProtein Interaction MappingProtein Serine-Threonine KinasesProteinsReceptors, Antigen, T-Cell, alpha-betaalpha-AmylasesEvaluation StudyJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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Rong Chen, Weiwei Tong, Julian Mintseris, Li Li, Zhiping Weng. 2003-07-01. ZDOCK predictions for the CAPRI challenge.. https://doi.org/10.1002/prot.10388

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