A protein-protein docking benchmark.

Rong Chen; Julian Mintseris; Joël Janin; Zhiping Weng

doi:10.1002/prot.10390

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A protein-protein docking benchmark.

Rong Chen·Julian Mintseris·Joël Janin·Zhiping Weng

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Abstract

We have developed a nonredundant benchmark for testing protein-protein docking algorithms. Currently it contains 59 test cases: 22 enzyme-inhibitor complexes, 19 antibody-antigen complexes, 11 other complexes, and 7 difficult test cases. Thirty-one of the test cases, for which the unbound structures of both the receptor and ligand are available, are classified as follows: 16 enzyme-inhibitor, 5 antibody-antigen, 5 others, and 5 difficult. Such a centralized resource should benefit the docking community not only as a large curated test set but also as a common ground for comparing different algorithms. The benchmark is available at (http://zlab.bu.edu/~rong/dock/benchmark.shtml).

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Algorithms Antibodies Antigens Binding Sites Enzyme Inhibitors Enzymes Macromolecular Substances Models, Molecular Protein Interaction Mapping Proteins Evaluation Study Journal Article Research Support, U.S. Gov't, Non-P.H.S.

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Rong Chen, Julian Mintseris, Joël Janin, Zhiping Weng. 2003-07-01. A protein-protein docking benchmark.. https://doi.org/10.1002/prot.10390

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