Lymphocyte lipid rafts: structure and function.

Paola Pizzo; Antonella Viola

doi:10.1016/s0952-7915(03)00038-4

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Lymphocyte lipid rafts: structure and function.

Paola Pizzo·Antonella Viola

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Abstract

Evidence has accumulated over the past few years to suggest that specialized plasma membrane regions enriched in cholesterol and glycolipids, called 'lipid rafts', are primarily involved in the initiation and propagation of the signal transduction cascade associated with lymphocyte activation. Considering the multitude of recent and often contradictory data, however, it appears that a critical reconsideration of the role of lipid rafts in lymphocyte activation is necessary and timely, particularly in light of a series of new experimental results that challenge the traditional view of the role of lipid rafts in lymphocyte activation.

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Animals Lymphocyte Activation Lymphocytes Membrane Microdomains Membrane Proteins Models, Biological Receptors, Immunologic Signal Transduction Journal Article Review

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Paola Pizzo, Antonella Viola. 2003. Lymphocyte lipid rafts: structure and function.. https://doi.org/10.1016/s0952-7915(03)00038-4

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