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Assembling atomic resolution views of the immunological synapse.

Jia-huai Wang·Michael J Eck
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Abstract

Antigen-dependent T-cell activation is initiated by the organized interactions of a host of cell-surface receptors in the interface between the T cell and an antigen-presenting cell. Recent structural studies of many of the receptors that comprise this 'immunological synapse', including integrins, cadherins and co-stimulatory molecules, reveal in detail the molecular interactions that bridge the synapse. Additionally, structural analyses of the cytoplasmic tails of integrins and co-stimulatory receptors in complex with intracellular signaling proteins are providing insight into the mechanisms that couple receptor clustering on the cell surface with the initiation of cytoplasmic signaling.

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AnimalsAntigen-Presenting CellsAntigens, CDCD4 AntigensCD8 AntigensCadherinsCell CommunicationGlycoproteinsImmunoglobulinsIntegrinsIntercellular Adhesion Molecule-1Lymphocyte ActivationModels, MolecularReceptors, Cell SurfaceReceptors, ImmunologicSignal TransductionSignaling Lymphocytic Activation Molecule Family Member 1T-LymphocytesJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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Jia-huai Wang, Michael J Eck. 2003. Assembling atomic resolution views of the immunological synapse.. https://doi.org/10.1016/s0952-7915(03)00055-4

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