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PubMed · 12787762

Migration and T-lymphocyte effector function.

Linda M Bradley
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Abstract

The development of immunity depends upon the capacity of responding T cells to become mobilized from lymphoid tissues where they are primed to sites of antigen exposure, wherever they occur in the body. Activation-induced alterations in the ability of T cells to migrate signify a fundamental change in biological function. Considerable attention is now focused on identifying mechanisms that regulate the migration and persistence of T cells that disseminate to non-lymphoid compartments as effector cells, and those that are retained in the lymphoid compartment. There are many unanswered questions about the developmental relationships and roles in protective immunity of antigen-experienced T cells that partition in different tissues.

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Cell MovementImmunologic MemoryModels, ImmunologicalT-Lymphocyte SubsetsT-LymphocytesJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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Linda M Bradley. 2003. Migration and T-lymphocyte effector function.. https://doi.org/10.1016/s0952-7915(03)00043-8

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