B cells as effectors.

Michael G McHeyzer-Williams

doi:10.1016/s0952-7915(03)00046-3

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B cells as effectors.

Michael G McHeyzer-Williams

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Abstract

B cells act as immune effectors, primarily through antigen-specific clonal expansion and plasma-cell differentiation. B1 (CD5(+)) B cells and marginal zone B cells dominate T-cell independent humoral responses under the molecular control of activated dendritic cells. Helper T cell-regulated B-cell responses draw on follicular B cells as precursors and rely on qualitatively different patterns of immune synapse formation to regulate B-cell fate. These activities culminate in the germinal center reaction, during which somatic hypermutation and antigen-driven selection produce and preserve high-affinity plasma cells with extended longevity and memory B cells as the sensitized precursors for antigen recall.

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Animals B-Lymphocytes Cell Differentiation Germinal Center Humans Immunologic Memory Mice Models, Immunological Plasma Cells T-Lymphocytes Journal Article Review

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Michael G McHeyzer-Williams. 2003. B cells as effectors.. https://doi.org/10.1016/s0952-7915(03)00046-3

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