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PubMed · 1279238

[Function, molecular structure and gene expression of granulocyte colony-stimulating factor].

S Asano
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Abstract

Human granulocyte colony-stimulating factor, a 19KD glycoprotein consisting of 174 amino acids, is one of the physiological regulators mainly produced by monocytes-macrophages, fibroblasts, and endothelial cells, under various stimulations such as neutropenias and infections. The molecule specifically and markedly stimulates the production of neutrophils associated with an expansion of the hemopoietic stem cells/progenitor cells, proliferates myeloid leukemia cells, releases these cells into blood, and elevates the functional activities of neutrophils. Under the favor of the activities, recombinant human granulocyte colony-stimulating factor has now become an epoch-making agents for the treatment of various disorders.

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Amino Acid SequenceBase SequenceGene Expression RegulationGranulocyte Colony-Stimulating FactorHumansMolecular Sequence DataEnglish AbstractJournal ArticleReview

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S Asano. 1992. [Function, molecular structure and gene expression of granulocyte colony-stimulating factor].. https://pubmed.ncbi.nlm.nih.gov/1279238/

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