PubMed · 12796962
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J C Hobbins. 1992-05-01. Get to know your machine.. https://doi.org/10.1046/j.1469-0705.1992.02030145.x
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Precision oncology relies on integrating tumour fraction, variant allele frequency, clonal haematopoiesis of indeterminate potential assessment, pathogenicity, and clinical context into next-generation sequencing interpretation, enabling biologically informed and clinically meaningful treatment decisions while reducing the risk of overinterpreting nontumour or nonactionable genomic alterations.