PubMed · 12796995
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S Campbell. 1992-01-01. A good start.. https://doi.org/10.1046/j.1469-0705.1992.02010001.x
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Precision oncology relies on integrating tumour fraction, variant allele frequency, clonal haematopoiesis of indeterminate potential assessment, pathogenicity, and clinical context into next-generation sequencing interpretation, enabling biologically informed and clinically meaningful treatment decisions while reducing the risk of overinterpreting nontumour or nonactionable genomic alterations.