Brain nitric oxide synthase is a haemoprotein.

P Klatt; K Schmidt; B Mayer

doi:10.1042/bj2880015

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PubMed · 1280109

Brain nitric oxide synthase is a haemoprotein.

P Klatt·K Schmidt·B Mayer

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Abstract

Brain nitric oxide (NO) synthase showed pyridine haemochrome spectra typical of ferroprotoporphyrin IX-containing enzymes. The haem content of purified NO synthase was in the range 0.7-0.9 mol/mol of 160 kDa subunit. In the presence of CO, NO, KCN and miconazole, the L-citrulline-forming activity of NO synthase was markedly diminished, demonstrating that enzyme-bound haem is involved in enzymic NO synthesis.

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Amino Acid Oxidoreductases Animals Brain Carbon Monoxide Citrulline Heme Miconazole Nitric Oxide Nitric Oxide Synthase Potassium Cyanide Spectrophotometry Swine Journal Article Research Support, Non-U.S. Gov't

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P Klatt, K Schmidt, B Mayer. 1992-11-15. Brain nitric oxide synthase is a haemoprotein.. https://doi.org/10.1042/bj2880015

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