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Extracellular glutamate decrease in accumbens following cued food delivery.

Mary Ann Chapman·John M Roll·Samuel Park·Matthew P Galloway
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Abstract

This study examined the effects of cued vs non-cued food delivery/consumption on extracellular glutamate and dopamine in the nucleus accumbens of food-deprived rats. Animals that always received a food pellet following a series of auditory tones showed a significant decrease in extracellular glutamate following food consumption, whereas animals that had not been previously exposed to tone-food pairing did not (p<0.05). In contrast, extracellular dopamine was significantly increased in the nucleus accumbens during the first time period after food consumption (p<0.05) regardless of whether animals had been exposed to prior tone-food pairing. Results suggest that food delivery/consumption is associated with a decrease in accumbal glutamate if food delivery has been previously paired with predictive environmental cues.

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Acoustic StimulationAnimalsCuesEatingExtracellular SpaceFood DeprivationGlutamic AcidMaleNucleus AccumbensRatsRats, Sprague-DawleyComparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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Mary Ann Chapman, John M Roll, Samuel Park, Matthew P Galloway. 2003-05-23. Extracellular glutamate decrease in accumbens following cued food delivery.. https://doi.org/10.1097/01.wnr.0000068556.33086.17

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