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PubMed · 1280672

Amylase-producing IgD-type multiple myeloma.

A Delannoy·J Hamels·C Mecucci·P Fally·G Wallef·C de Fooz·B Carlier
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Abstract

We describe the case of a 63-year-old woman with an IgD-type multiple myeloma and hyperamylasaemia. The evolution of the amylase concentration, the immunohistochemical data and the intracellular amylase contents of the plasma cell were consistent with secretion of amylase by the malignant clone. Moreover, cytogenetic analysis of the bone marrow revealed two structural rearrangements involving chromosome 1 near the amylase locus. Multiple myeloma should be added to the amylase-secreting tumours. This rare entity is not confined to Japan, where it was first recognized.

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Adrenal Cortex HormonesAmylasesBone Marrow ExaminationChromosome AberrationsChromosome DisordersChromosomes, Human, Pair 1CyclophosphamideDrug Therapy, CombinationElectrophoresis, Agar GelFemaleGene DeletionGene RearrangementHumansImmunoenzyme TechniquesImmunoglobulin DKaryotypingMiddle AgedMultiple MyelomaPlasma CellsRenal DialysisWhite PeopleCase ReportsJournal ArticleReview

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A Delannoy, J Hamels, C Mecucci, P Fally, G Wallef, C de Fooz, B Carlier. 1992. Amylase-producing IgD-type multiple myeloma.. https://doi.org/10.1111/j.1365-2796.1992.tb00615.x

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