[Recent progress in the "fibrinogen hypothesis"].

P Lefebvre; Th Ledent; J Ducobu

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PubMed · 12806874

[Recent progress in the "fibrinogen hypothesis"].

P Lefebvre·Th Ledent·J Ducobu

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Abstract

Several clinical and epidemiological studies have demonstrated that a high level of plasma fibrinogen is an independent risk factor for coronary, cerebral and peripheral artery disease. The role of fibrinogen in cardiovascular diseases is mainly due to thrombotic complications in advanced stages of the atherothrombotic disease. However, fibrinogen also plays an active role in the initiation and development of atheromatous plaques. The relations between fibrinogen and ischemic cardiopathies, other vasculopathies and diabetes mellitus are discussed. The controversial effects of statins on fibrinogen are also described.

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Biomarkers Cardiovascular Diseases Cerebrovascular Disorders Diabetes Complications Fibrinogen Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Peripheral Vascular Diseases Risk Factors English Abstract Journal Article Review

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P Lefebvre, Th Ledent, J Ducobu. 2003. [Recent progress in the "fibrinogen hypothesis"].. https://pubmed.ncbi.nlm.nih.gov/12806874/

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