Maximum likelihood estimation and identification directly from single-channel recordings.

D R Fredkin; J A Rice

doi:10.1098/rspb.1992.0094

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Maximum likelihood estimation and identification directly from single-channel recordings.

D R Fredkin·J A Rice

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Abstract

We present a method for analysis of noisy sampled data from a single-channel patch clamp which bypasses restoration of an idealized quantal signal. We show that, even in the absence of a specific model, the conductance levels and mean dwell times within those levels can be estimated. Estimation of the rate constants of a hypothesized kinetic scheme is more difficult. We present examples in which the rate constants can be effectively estimated and examples in which they cannot.

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Animals Electric Conductivity Ion Channels Kinetics Mathematics Models, Biological Probability Time Factors Journal Article Research Support, U.S. Gov't, Non-P.H.S.

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D R Fredkin, J A Rice. 1992-08-22. Maximum likelihood estimation and identification directly from single-channel recordings.. https://doi.org/10.1098/rspb.1992.0094

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