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Decrease of ethanol intake following repeated injection of serotonin-1A agonist in rats: relationship with receptor responsiveness.

Ambreen Hasnat·Saida Haider·Tahira Perveen·I M Kidwai·Darakhshan J Haleem
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Abstract

OBJECTIVE: To monitor pre and postsynaptic receptor responsiveness and consumption of ethanol following the repeated administration of a selective serotonin-1A receptor agonist, 8-hydroxy-2-di-n-propylaminotetralin (8-OH-DPAT), to ethanol treated rats. DESIGN: The experimental protocol was designed to administer ethanol orally to rats for three weeks and 8-OH-DPAT during the 3rd week. PLACE AND DURATION OF STUDY: The experiments were performed in the department of Biochemistry, Karachi University. Samples collected after three weeks of treatment were analyzed within a week. SUBJECTS AND METHODS: The study was conducted on 24 males albino Wistar rats treated with ethanol for three weeks. 8-OH-DPAT at a dose of 1mg/kg or saline was injected to ethanol treated rats from day 1 to day 5 during the 3rd week to monitor the effects on ethanol consumption. Pre and postsynaptic responses to 8-OH-DPAT were monitored by injecting the drug on the 6th day to a group of 5-day saline and a group of 5-day 8-OH-DPAT injected animals. Control animals of the two groups were injected with saline. RESULTS: Before the injection of 8-OH-DPAT, weekly intakes of ethanol were highly comparable in the two groups. Administration of 8-OH-DPAT, from day 1 to day 5, decreased ethanol intake. Pre and postsynaptic serotonin-1A receptor dependent responses monitored on the 6th day were higher in 5-day saline than 5-day 8-OH-DPAT injected animals. CONCLUSION: A decrease in the effectiveness of negative feedback control over the synaptic availability of serotonin following 5-day administration of 8-OH-DPAT is involved in the decreases of ethanol consumption.

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8-Hydroxy-2-(di-n-propylamino)tetralinAlcohol DrinkingAnimalsEthanolFeedback, PhysiologicalMaleModels, AnimalRatsRats, WistarReceptors, SerotoninSerotonin Receptor AgonistsEvaluation StudyJournal ArticleResearch Support, Non-U.S. Gov't

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Ambreen Hasnat, Saida Haider, Tahira Perveen, I M Kidwai, Darakhshan J Haleem. 2003. Decrease of ethanol intake following repeated injection of serotonin-1A agonist in rats: relationship with receptor responsiveness.. https://doi.org/06.2003/jcpsp.305308

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