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PubMed · 1281638

B-cell tolerance.

C C Goodnow
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Abstract

Discrimination between self and non-self in humoral immunity is mediated in part by elimination or inactivation of self-reactive B-cell clones. This type of repertoire censoring requires that self-reactive B cells make a choice between these and alternative cellular fates. The details of this developmental decision-making and the steps where it is prone to go awry in autoimmunity have yet to be untangled, but genetic analysis appears likely to lead the way.

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AnimalsAntigens, SurfaceAutoantibodiesAutoimmunityB-LymphocytesHumansImmune ToleranceMiceMice, Inbred NZBProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2fas ReceptorJournal ArticleReview

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BibTeXRIS

C C Goodnow. 1992. B-cell tolerance.. https://doi.org/10.1016/0952-7915(92)90049-k

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