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Is black cohosh estrogenic?

Gail B Mahady
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Abstract

Many women seek safe and effective alternative therapies for the treatment of menopausal symptoms. Black cohosh, a botanical product, is one such treatment. Its mechanism of action may involve estrogenic effects, but new data dispute the estrogenic theory and indicate that extracts of black cohosh do not bind to the estrogen receptor, up-regulate estrogen-dependent genes, or stimulate the growth of estrogen-dependent tumors in animal models.

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AnimalsCimicifugaEstrogensFemaleGene Expression RegulationHumansMenopauseNeoplasms, ExperimentalPlant ExtractsReceptors, EstrogenJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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Gail B Mahady. 2003. Is black cohosh estrogenic?. https://doi.org/10.1301/nr.2003.may.183-186

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