Mutagenesis approaches to deduce structure-function relationships in terpene synthases.

Michael J R Segura; Beth E Jackson; Seiichi P T Matsuda

doi:10.1039/b008338k

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Mutagenesis approaches to deduce structure-function relationships in terpene synthases.

Michael J R Segura·Beth E Jackson·Seiichi P T Matsuda

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Abstract

This review highlights mutagenesis studies of terpene synthases, specifically sesquiterpene synthases and oxidosqualene cyclases. Mutagenesis studies of these enzymes have provided mechanistic insights, structure-function relationships for specific enzymatic residues, novel terpene structures and enzymes with novel activities. The literature through 2002 is reviewed and 113 references cited.

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Alkyl and Aryl Transferases Amino Acid Sequence Catalysis Mutagenesis Plants Structure-Activity Relationship Terpenes Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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Michael J R Segura, Beth E Jackson, Seiichi P T Matsuda. 2003. Mutagenesis approaches to deduce structure-function relationships in terpene synthases.. https://doi.org/10.1039/b008338k

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