Y-box binding protein expression in thyroid neoplasms: its linkage with anaplastic transformation.

Yasuhiro Ito; Hiroshi Yoshida; Kotaro Shibahara; Takashi Uruno; Keiichi Nakano; Yuuki Takamura; Akihiro Miya; Kaoru Kobayashi; Tamotsu Yokozawa; Fumio Matsuzuka; Takeshi Uchimi; Michihiko Kuwano; Eiji Miyoshi; Nariaki Matsuura; Kanji Kuma; Akira Miyauchi

doi:10.1046/j.1440-1827.2003.01494.x

PubMed · 12828607

Y-box binding protein expression in thyroid neoplasms: its linkage with anaplastic transformation.

Yasuhiro Ito·Hiroshi Yoshida·Kotaro Shibahara·Takashi Uruno·Keiichi Nakano·Yuuki Takamura·Akihiro Miya·Kaoru Kobayashi·Tamotsu Yokozawa·Fumio Matsuzuka·Takeshi Uchimi·Michihiko Kuwano·Eiji Miyoshi·Nariaki Matsuura·Kanji Kuma·Akira Miyauchi

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Abstract

Recent studies have demonstrated that Y-box binding protein (YB-1) regulates the transcription of genes linked to carcinoma progression. In this study, we investigated the expression of this protein in thyroid neoplasms to elucidate its significance. The expression of YB-1 was immunohistochemically investigated using the monoclonal antibody for various thyroid neoplasms. Normal follicles did not overexpress YB-1, and only moderate overexpression of YB-1 was observed in some follicular tumors and papillary carcinoma, especially those of a larger size. In contrast, 92.9% of anaplastic carcinoma strongly overexpressed YB-1. YB-1 immunoreactivity was seen in both cytoplasms and cell nuclei, but the former was more predominant. These findings suggest that YB-1 plays a role in regulating the transcription as well as translation of genes contributing to the anaplastic transformation of thyroid carcinoma.

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Adenocarcinoma, Follicular Adenocarcinoma, Papillary CCAAT-Enhancer-Binding Proteins Carcinoma Cell Transformation, Neoplastic DNA-Binding Proteins Humans Immunoenzyme Techniques Ki-67 Antigen NFI Transcription Factors Nuclear Proteins Thyroid Gland Thyroid Neoplasms Transcription Factors Y-Box-Binding Protein 1 Journal Article

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Yasuhiro Ito, Hiroshi Yoshida, Kotaro Shibahara, Takashi Uruno, Keiichi Nakano, Yuuki Takamura, Akihiro Miya, Kaoru Kobayashi, Tamotsu Yokozawa, Fumio Matsuzuka, Takeshi Uchimi, Michihiko Kuwano, Eiji Miyoshi, Nariaki Matsuura, Kanji Kuma, Akira Miyauchi. 2003. Y-box binding protein expression in thyroid neoplasms: its linkage with anaplastic transformation.. https://doi.org/10.1046/j.1440-1827.2003.01494.x

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