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PubMed · 12829244

Search for new cyclic AMP-binding proteins.

S Dremier·R Kopperud·S O Doskeland·J E Dumont·C Maenhaut
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Abstract

Today, there is evidence that the cAMP-dependent kinases (PKA) are not the only intracellular receptors involved in intracellular cAMP signalling in eukaryotes. Other cAMP-binding proteins have been recently identified, including some cyclic nucleotide-gated channels and Epac (exchange protein directly activated by cAMP) proteins. All these proteins bind cAMP through conserved cyclic nucleotide monophosphate-binding domains. However, all putative cAMP-binding proteins having such domains, as revealed by computer analysis, do not necessarily bind cAMP, indicating that their presence is not a sufficient criteria to predict cAMP-binding property for a protein.

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Amino Acid SequenceAnimalsConsensus SequenceCyclic AMPCyclic AMP Receptor ProteinCyclic AMP-Dependent Protein KinasesHumansIon Channel GatingMolecular Sequence DataProtein Structure, SecondarySequence Homology, Amino AcidSignal TransductionJournal ArticleResearch Support, Non-U.S. Gov'tReview

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S Dremier, R Kopperud, S O Doskeland, J E Dumont, C Maenhaut. 2003-07-03. Search for new cyclic AMP-binding proteins.. https://doi.org/10.1016/s0014-5793(03)00561-1

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