A mathematical programming approach for gene selection and tissue classification.

Minghe Sun; Momiao Xiong

doi:10.1093/bioinformatics/btg145

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A mathematical programming approach for gene selection and tissue classification.

Minghe Sun·Momiao Xiong

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Abstract

MOTIVATION: Extracting useful information from expression levels of thousands of genes generated with microarray technology needs a variety of analytical techniques. Mathematical programming approaches for classification analysis outperform parametric methods when the data depart from assumptions underlying these methods. Therefore, a mathematical programming approach is developed for gene selection and tissue classification using gene expression profiles. RESULTS: A new mixed integer programming model is formulated for this purpose. The mixed integer programming model simultaneously selects genes and constructs a classification model to classify two groups of tissue samples as accurately as possible. Very encouraging results were obtained with two data sets from the literature as examples. These results show that the mathematical programming approach can rival or outperform traditional classification methods.

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Algorithms Cluster Analysis Connective Tissue Cells Gene Expression Profiling Humans Leukemia, Myeloid, Acute Models, Genetic Neoplasm Proteins Oligonucleotide Array Sequence Analysis Pattern Recognition, Automated Precursor Cell Lymphoblastic Leukemia-Lymphoma Reproducibility of Results Sensitivity and Specificity Sequence Alignment Sequence Analysis Comparative Study Evaluation Study Journal Article Validation Study

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Minghe Sun, Momiao Xiong. 2003-07-01. A mathematical programming approach for gene selection and tissue classification.. https://doi.org/10.1093/bioinformatics%2Fbtg145

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