Does anti-aging equal anti-microbial?

Gordon J Lithgow

doi:10.1126/sageke.2003.25.pe16

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Does anti-aging equal anti-microbial?

Gordon J Lithgow

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Abstract

Aging is the dominant risk factor for human disease in developed countries. Could it be that a wide variety of disease states all have their origins in a common mechanism? Major signaling pathways that determine the rate of aging, such as the insulin/insulin-like growth factor 1 (IGF-1) pathway, might give clues to the nature of this major disease risk factor. It has now been shown that insulin/IGF-1 signaling influences Caenorhabditis elegans resistance to bacteria in such a way that long-lived worms are stress-resistant and slow to succumb to infection. Perhaps enhanced innate immunity is a feature of genetically determined longevity.

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Aging Animals Caenorhabditis elegans Caenorhabditis elegans Proteins Genes, Helminth Insulin Insulin-Like Growth Factor I Phosphatidylinositol 3-Kinases Receptor, Insulin Signal Transduction Journal Article

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Gordon J Lithgow. 2003-06-25. Does anti-aging equal anti-microbial?. https://doi.org/10.1126/sageke.2003.25.pe16

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