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PubMed · 1284733

ABO-incompatible bone marrow transplantation.

M Wiesneth·B Hertenstein·D Bunjes·T Schmeiser·B Maccari·H Northoff·H Laasch·W Heit·R Arnold·H Heimpel
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Abstract

In the past 10 years 201 HLA-identical bone marrow transplantations (BMT) were performed with major ABO incompatibility in 41 (20%) and minor ABO incompatibility in 35 (18%) patients. ABO compatibility between donor and recipient showed no influence on granulocyte and platelet recovery after BMT. Erythrocyte reconstitution was significantly (p < 0.01) delayed for about 1 week in major ABO-incompatible BMT. In addition, a pure red cell aplasia lasting for 2-5 months occurred in 6 out of 21 blood group 0 patients who received transplants of group A. The rate of graft rejection, incidence of graft-versus-host disease as well as the leukemic relapse rate were similar in ABO-compatible and ABO-incompatible BMT. The probability of a 10-year survival after BMT is independent of ABO compatibility between donor and recipient.

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ABO Blood-Group SystemAdolescentAdultBlood Group IncompatibilityBone Marrow TransplantationFemaleGraft RejectionGraft vs Host DiseaseHematopoiesisHemolysisHistocompatibility TestingHumansMaleMiddle AgedRed-Cell Aplasia, PureRetrospective StudiesJournal Article

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M Wiesneth, B Hertenstein, D Bunjes, T Schmeiser, B Maccari, H Northoff, H Laasch, W Heit, R Arnold, H Heimpel. 1992. ABO-incompatible bone marrow transplantation.. https://pubmed.ncbi.nlm.nih.gov/1284733/

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