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PubMed · 12848953

Cryptic infection and autoimmunity.

Adam Pleister·David D Eckels
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Abstract

Infection as an environmental factor in autoimmunity has long been recognized. Numerous examples can be found in which pathogens express antigens that cross-react with host antigens or induce local inflammatory responses that can lead to autoimmune responses through a very complex set of circumstances. Borrowing from the relationship between chronic infection with hepatitis C virus and autoimmune hepatitis as an example, we consider the possibility that infection with an unknown virus having specific tissue tropism could lead to a perceived autoimmune process. We raise the question whether such should be considered for Type 1 diabetes.

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AnimalsAutoimmunityDiabetes Mellitus, Type 1HepacivirusHumansInfectionsModels, ImmunologicalJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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Adam Pleister, David D Eckels. 2003. Cryptic infection and autoimmunity.. https://doi.org/10.1016/s1568-9972(03)00003-x

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