Antiphospholipid syndrome: pathogenic mechanisms.

Gerard Espinosa; Ricard Cervera; Josep Font; Yehuda Shoenfeld

doi:10.1016/s1568-9972(02)00144-1

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Antiphospholipid syndrome: pathogenic mechanisms.

Gerard Espinosa·Ricard Cervera·Josep Font·Yehuda Shoenfeld

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Abstract

Despite the strong association between antiphospholipid antibodies (aPL) and thrombosis, the pathogenic role of aPL in the development of thrombosis has not been fully elucidated. Proposed pathophysiological mechanisms may be categorized into two types. First, aPL may act in vivo by disrupting the kinetics of the normal procoagulant and anticoagulant reactions occurring on cell membranes. Second, aPL may stimulate certain cells thereby altering the expression and secretion of various molecules. In this article, we review the mechanisms by which aPL may develop thrombotic events.

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Animals Antibodies, Antiphospholipid Antiphospholipid Syndrome Blood Coagulation Fibrinolysis Humans Models, Biological Thrombosis Journal Article Review

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Gerard Espinosa, Ricard Cervera, Josep Font, Yehuda Shoenfeld. 2003. Antiphospholipid syndrome: pathogenic mechanisms.. https://doi.org/10.1016/s1568-9972(02)00144-1

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