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Is synaptotagmin the calcium sensor?

Motojiro Yoshihara·Bill Adolfsen·J Troy Littleton
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Abstract

After much debate, recent progress indicates that the synaptic vesicle protein synaptotagmin I probably functions as the calcium sensor for synchronous neurotransmitter release. Following calcium influx into presynaptic terminals, synaptotagmin I rapidly triggers the fusion of synaptic vesicles with the plasma membrane and underlies the fourth-order calcium cooperativity of release. Biochemical and genetic studies suggest that lipid and SNARE interactions underlie synaptotagmin's ability to mediate the incredible speed of vesicle fusion that is the hallmark of fast synaptic transmission.

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AnimalsCalciumCalcium-Binding ProteinsHumansMembrane GlycoproteinsMutationNerve Tissue ProteinsSynaptic VesiclesSynaptotagmin ISynaptotagminsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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Motojiro Yoshihara, Bill Adolfsen, J Troy Littleton. 2003. Is synaptotagmin the calcium sensor?. https://doi.org/10.1016/s0959-4388(03)00063-1

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