The dynamic organization of postsynaptic proteins: translocating molecules regulate synaptic function.

Akihiro Inoue; Shigeo Okabe

doi:10.1016/s0959-4388(03)00077-1

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The dynamic organization of postsynaptic proteins: translocating molecules regulate synaptic function.

Akihiro Inoue·Shigeo Okabe

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Abstract

Physiological roles for postsynaptic molecules in synaptogenesis and plasticity are under intense investigation. Recent imaging experiments, including GFP-based and single-particle tracking strategies, reveal rapid movement of synaptic components to and from the postsynaptic sites. Furthermore, specific patterns of neuronal activity and/or activation of specific transmitter receptors trigger selective translocation of postsynaptic components. These emerging dynamic properties of synaptic specializations add another layer of complexity to the signaling mechanisms of CNS synapses.

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Animals Humans Presynaptic Terminals Proteins Receptors, Glutamate Synapses Journal Article Research Support, Non-U.S. Gov't Review

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Akihiro Inoue, Shigeo Okabe. 2003. The dynamic organization of postsynaptic proteins: translocating molecules regulate synaptic function.. https://doi.org/10.1016/s0959-4388(03)00077-1

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